Download Parkinson's disease-BPT PDF

TitleParkinson's disease-BPT
TagsNeuroscience Psychoactive Drugs Parkinson's Disease Medical Treatments Neurological Disorders
File Size541.8 KB
Total Pages15
Document Text Contents
Page 1

ParkinsonismParkinsonism

Dr.Rathnakar U.P.Dr.Rathnakar U.P.
MD.DIH.PGDHMMD.DIH.PGDHM

BPTBPT

20 NOV 201320 NOV 2013

Page 2

ContentsContents

•• Examples of antiparkinsonian drugsExamples of antiparkinsonian drugs

••  Adverse ef Adverse effects of lefects of levodopavodopa

•• Basis for combining levodopa withBasis for combining levodopa with
carbidopacarbidopa

•• Drugs used in drug-induced parkinsonismDrugs used in drug-induced parkinsonism
and their mechanism of actionand their mechanism of action

Page 7

Sites of action of drugs used to treat Sites of action of drugs used to treat Parkinson's diseaseParkinson's disease

LevodopaLevodopa 3-MDOPA3-MDOPADopamineDopamine

DDC COMTDDC COMT

EntacaponeEntacapone
TolcaponeTolcapone

CarbidopaCarbidopa
BenserazideBenserazide

BBBBBBBBBBBB

LevodopaLevodopa

Dopamine 3MTDopamine 3MTDOPACDOPAC

COMTCOMTMAOBMAOB

SelegilineSelegiline
RasagilineRasagiline

TolcaponeTolcapone

DD11 & D & D22
ReceptorsReceptors

DA agonistsDA agonists

11

22 22

3333

44

AnticholinergicsAnticholinergics
•• TrihexyphenidylTrihexyphenidyl
•• ProcyclidineProcyclidine

•• BiperidenBiperiden
•• AntihistaminicsAntihistaminics

55

00
StupidStupid

66

DA facilitatorDA facilitator
AmantadineAmantadine

Page 8

Drugs for PDDrugs for PD

I.Drugs affecting brain dopaminergicI.Drugs affecting brain dopaminergic

systemsystem

1.1. DA pDA precrecurursosor-r- LevodopaLevodopa

2.2. DDC DDC inhinhibiibitortors-s-CarbidopaCarbidopa

3.3. DA DA agagononisists-ts-

BromocriptineBromocriptine

4.4. MAOMAO-B -B inhinhibiibitortors-s-

SelegilineSelegiline

5.5. COMCOMT T inhinhibiibitorstors--

EntacaponeEntacapone

6.6. DA DA facfaciliilitattator-or-AmantadineAmantadine

II.Drugs affecting brain cholinergicII.Drugs affecting brain cholinergic

systemsystem

1.1. CeCenntrtral aal antnticichoholilinenergrgicicss

Trihexyphenydyl,Trihexyphenydyl,

procyclidine, biperidenprocyclidine, biperiden

2. Antihistaminics2. Antihistaminics

Orphenadrine,Orphenadrine,

promethazinepromethazine

Similer Documents